Evolutionary History of the Human Genome
نویسنده
چکیده
Compositional genomics is an approach to the problem of the organization of eukaryotic genomes. Initially this approach consisted of analysing the base composition of complex eukaryotic genomes (such as the nuclear genomes of vertebrates) by using density gradient centrifugation in the presence of sequence-specific ligands. This approach revealed that vertebrate genomes are mosaics of very long stretches of deoxyribonucleic acid (DNA) with fairly homogeneous GC levels (the percentage of guanine+cytosine), the isochores, which belong to a small number of families characterized by different base compositions. This compositional approach was extended to nucleotide sequences when these became available. When comparative studies were made of the organization of the nuclear genomes of vertebrates, compositional differences were found and were shown to have an evolutionary relevance. See also: Genome Organization of Vertebrates; Isochores
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